Stromal Vascular Fractions (SVFs)
Stromal Vascular Fractions (SVFs): Overview and Medical Applications
What are SVFs?
Stromal Vascular Fractions (SVFs) are a heterogeneous mixture of cells derived from adipose tissue (fat). These cells are not the same as stem cells but contain a high concentration of various cell types with regenerative potential, including mesenchymal stromal cells, endothelial progenitor stem cells, leukocytes, and pericytes. SVF is obtained through enzymatic digestion of fat tissue, often via liposuction, and is being researched for its roles in tissue regeneration, immunomodulation, and angiogenesis.
Key Components of SVF
- Mesenchymal Stromal Cells (MSCs): Capable of differentiating into adipocytes, osteocytes, chondrocytes, and myocytes.
- Endothelial Progenitor Stem Cells: Support blood vessel formation (angiogenesis).
- Leukocytes: Play roles in immune regulation.
- Growth Factors and Cytokines: Promote wound healing, tissue repair, and regeneration.
Clinical Applications and Benefits
SVF has a broad spectrum of potential clinical uses, including:
- Repair of orthopedic injuries and degenerative joint diseases.
- Treatment of neurodegenerative diseases and ischemic conditions.
- Wound healing, chronic ulcer management, and tissue revitalization.
- Rejuvenation in aesthetic procedures.
- Potential treatment for autoimmune diseases and infertility.
Developmental and clinical trials are ongoing worldwide, highlighting SVF’s regenerative capabilities and safety profile, making it a promising option in regenerative medicine.
How is SVF Used?
- Injections: Directly injected into tissues needing repair or regeneration.
- Cultured and Expanded: SVF can be cultured in labs to produce more stem cells for future use.
- Combination Therapies: Used alongside other regenerative procedures for improved outcomes.
Key Points
- SVF is a versatile mix of regenerative cells from fat tissue.
- Contains stem cell populations capable of multilineage differentiation.
- Facilitates tissue repair, angiogenesis, and immune modulation.
- Used in orthopedics, wound healing, neurodegenerative conditions, and aesthetic treatments.
- Ongoing research aims to standardize protocols and expand clinical applications.
Consult with Our Team of Experts Now!
For more information, consult our specialists about the potential of SVF therapies for regenerative medicine including Cellular Therapy and Stem Cell and aesthetic procedures.
References:
Gareev I, et al. Stromal vascular fraction cell therapy: A promising regenerative treatment. Front Cell Dev Biol. 2025;13:954321. doi:10.3389/fcell.2025.954321. Available at: https://www.sciencedirect.com/science/article/pii/S2589238X25000154
