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Pressure ulcers (PU)-also known as bedsores, pressure sores, decubitus ulcers, or pressure injuries-are localized injuries to the skin and underlying tissue, typically occurring over bony prominences as a result of prolonged pressure, often combined with shear, friction, or moisture17. These ulcers are a significant concern in immobile or bedridden individuals, such as those with paralysis, chronic illness, or after surgery256.

Pressure Ulcers (PU)

Pressure ulcers-also known as bedsores, pressure sores, decubitus ulcers, or pressure injuries-are localized injuries to the skin and underlying tissue, typically occurring over bony prominences as a result of prolonged pressure, often combined with shear, friction, or moisture17. These ulcers are a significant concern in immobile or bedridden individuals, such as those with paralysis, chronic illness, or after surgery256..

Pressure Ulcers (PU)

Pressure ulcers (PU)-also known as bedsores, pressure sores, decubitus ulcers, or pressure injuries-are localized injuries to the skin and underlying tissue, typically occurring over bony prominences as a result of prolonged pressure, often combined with shear, friction, or moisture17. These ulcers are a significant concern in immobile or bedridden individuals, such as those with paralysis, chronic illness, or after surgery256.

Causes and Risk Factors

  • Prolonged Pressure: Constant pressure, especially over bony areas (sacrum, heels, hips, elbows), impedes blood flow, leading to tissue ischemia and cell death1257.
  • Shear: Sliding movements stretch and tear blood vessels, worsening tissue damage127.
  • Friction: Rubbing against bedding or clothing removes superficial skin layers, increasing vulnerability27.
  • Moisture: Incontinence or sweating weakens skin, making it more susceptible to breakdown27.
  • Risk Factors: Immobility, poor nutrition, incontinence, reduced sensation, advanced age, vascular disease, and previous pressure ulcers increase susceptibility2567.

Common Sites

  • Sacrum and coccyx
  • Heels
  • Hips
  • Elbows, knees, ankles, shoulders, and back of the head7

Stages of Pressure Ulcers

Pressure ulcers are classified by depth and severity37:

StageDescription
Stage 1Non-blanchable redness of intact skin; may feel warm, spongy, or hard; possible pain/itching34
Stage 2Partial-thickness skin loss involving epidermis and/or dermis; shallow open ulcer or blister3
Stage 3Full-thickness skin loss; damage or necrosis of subcutaneous tissue, possibly visible fat3
Stage 4Full-thickness tissue loss with exposed muscle, bone, or tendon; high risk of infection3

Symptoms

  • Redness or discoloration (may appear as purple/blue in darker skin)
  • Localized warmth, swelling, or hardness
  • Pain, tenderness, or itching
  • Open sores or wounds, sometimes with drainage or foul odor
  • In severe cases, visible muscle, bone, or eschar (dead tissue)347

Diagnosis

  • Clinical Evaluation: Physical exam, assessment of location, depth, and appearance2.
  • Staging: Classifying the ulcer guides treatment and monitoring23.
  • Nutritional Assessment: Poor nutrition impedes healing2.
  • Further Testing: Blood tests, wound cultures, and imaging (MRI) may be used to assess complications like infection or osteomyelitis2.

Treatment

  • Pressure Relief: Regular repositioning and use of specialized mattresses/cushions to reduce pressure6.
  • Wound Care: Cleaning, debridement (removal of dead tissue), and appropriate dressings6.
  • Infection Control: Topical or systemic antibiotics if infection is present6.
  • Supportive Care: Maintaining good nutrition and hydration to promote healing26.
  • Surgery: May be required for severe (stage 3 or 4) ulcers that do not heal with conservative measures36.

Prevention

  • Frequent repositioning (every 2 hours if bedridden)
  • Use of pressure-relieving devices (mattresses, cushions)
  • Daily skin checks, especially over bony prominences
  • Maintaining skin hygiene and dryness
  • Adequate nutrition and hydration
  • Avoiding smoking67

Complications

  • Local and systemic infections (cellulitis, osteomyelitis, sepsis)
  • Chronic pain
  • Delayed healing or recurrence
  • Increased healthcare costs and hospital stays7

Summary Table

AspectDetails
Other NamesBedsores, decubitus ulcers, pressure sores, pressure injuries
CausesProlonged pressure, shear, friction, moisture
Risk FactorsImmobility, poor nutrition, incontinence, vascular disease, reduced sensation
Common SitesSacrum, heels, hips, elbows, ankles, shoulders, back of head
Staging1 (redness) → 2 (blister/partial thickness) → 3 (full thickness) → 4 (deep tissue loss)
PreventionRepositioning, pressure-relieving devices, skin care, nutrition
TreatmentPressure relief, wound care, infection control, surgery (severe cases)
ComplicationsInfection, sepsis, chronic wounds, increased healthcare costs

Consult with Our Team of Experts Now!
At DrStemCellsThailand (DRSCT)‘s Anti-Aging and Regenerative Medicine Center of Thailand, we emphasize comprehensive evaluations and personalized treatment plans of Cellular Therapy and Stem Cells for managing various health conditions. If you have questions about Neuromodulation Programs (NMP) or would like more information on our services, consult with our experts today!

Consult with Our Team of Experts Now!

Pressure ulcers are preventable injuries that require early identification, risk assessment, and a multidisciplinary approach to management and prevention to reduce morbidity and improve patient outcomes167.

References:

A thorough overview of pressure ulcers-including risk factors, pathophysiology, complications, prevention, and treatment-is provided in “Elucidation about pressure ulcers” (DOI: 10.33448/rsd-v11i16.38341).

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