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Organoids (OGS): Understanding Their Definition, Properties, and Applications

Organoids (OGS) are three-dimensional (3D) miniature structures that mimic the key functional, structural, and biological complexity of organs. They are derived from Cellular Therapy and Stem Cells and progenitor stem cells, which self-organize in culture to acquire in vivo-like organ complexity12.

Properties of Organoids (OGS)

1. Cellular Complexity:
   Organoids contain multiple organ-specific cell types and are capable of recapitulating some specific functions of the organ, such as contraction, neural activity, or endocrine secretion14.
2. Spatial Organization:
   The cells in organoids are grouped together and spatially organized, similar to an organ, allowing them to mimic the morphology and functions of their in vivo counterparts46.
3. Self-Organization:
   Organoids self-organize through cell sorting and spatially restricted lineage commitment, similar to in vivo development16.

Applications of Organoids

1. Basic Research and Disease Modeling:
   Organoids are used to study development, homeostasis, and disease in the laboratory. They provide a platform for understanding disease progression and testing therapeutic interventions23.
2. Drug Discovery and Drug Development:
   Organoids are valuable for drug screening and testing due to their ability to mimic human tissue responses, allowing for more accurate predictions of drug efficacy and toxicity34.
3. Personalized Medicine and Regenerative Medicine:
   Organoids derived from patient cells can be used for personalized diagnostics and therapies, offering potential for tailored treatments and tissue repair38.
4. Gene and Cell Therapies:
   Organoids can be used to study gene editing technologies like CRISPR/Cas9, facilitating gene therapy approaches by allowing precise manipulation of genetic material within a controlled environment13.

Conclusion

Organoids represent a significant advancement in biomedical Research and Clinical Trials, offering a powerful tool for understanding human biology, modeling diseases, and developing personalized therapies.

Consult with Our Team of Experts Now!
At DrStemCellsThailand‘s Anti-Aging and Regenerative Medicine Center of Thailand, we emphasize comprehensive evaluations and personalized treatment plans of Cellular Therapy and Stem Cells for managing health conditions using cutting-edge technologies like organoids. If you have questions about organoids or would like more information on our services related to regenerative medicine, consult with our experts today!

Consult with Our Team of Experts Now!

References

1. Wikipedia: Organoid
   Discusses the definition, properties, and applications of organoids in research and medicine.
2. PMC: Human Organoids
   Highlights the use of organoids in studying human tissue dynamics and disease modeling.
3. Nature: Human Organoids in Basic Research and Clinical Applications
   Reviews the applications of organoids in drug discovery, personalized medicine, and regenerative medicine.
4. PMC: Organoids – Current Status and Biomedical Applications
   Discusses the potential of organoids in drug screening and disease modeling.
5. Sinobiological: Organoids
   Explains the classification and culture techniques of organoids.
6. Nature Reviews Methods Primers: Organoids
   Provides insights into organoid engineering strategies and applications in diagnostics and personalized medicine.
7. NCI Dictionary of Cancer Terms: Organoid
   Defines organoids in the context of cancer research.
8. EuroGCT: Organoids in Regenerative Medicine
   Discusses the role of organoids in regenerative medicine and tissue repair.