Neurodegeneration (NDG)

Definition
Neurodegeneration (NDG) refers to the progressive loss of structure or function of neurons, including their death. This process is often associated with various neurological disorders that can lead to significant cognitive, motor, and functional impairments. Neurodegenerative diseases include conditions such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS).

Importance of Neurodegeneration

Impact on Quality of Life: Neurodegenerative diseases significantly affect patients’ quality of life by impairing cognitive function, mobility, and daily living activities.
Economic Burden: These diseases pose a substantial economic burden on healthcare systems due to the need for long-term care and treatment.
Research and Treatment Challenges: Understanding the mechanisms underlying neurodegeneration is crucial for developing effective treatments. Current therapies often focus on symptom management rather than reversing the underlying neurodegenerative processes.

Mechanisms of Neurodegeneration
Several mechanisms contribute to neurodegeneration:

Protein Misfolding and Aggregation: Abnormal protein accumulation in neurons can lead to cellular dysfunction and death. For example, amyloid-beta plaques are characteristic of Alzheimer’s disease.
Oxidative Stress: An imbalance between free radicals and antioxidants in the body can damage neuronal cells, contributing to neurodegeneration.
Inflammation: Chronic inflammation in the brain can exacerbate neuronal damage and promote the progression of neurodegenerative diseases.
Mitochondrial Dysfunction: Impaired mitochondrial function can lead to energy deficits in neurons, resulting in cell death.

At DrStemCellsThailand‘s Anti-Aging and Regenerative Medicine Center of Thailand, our specialized treatment protocols utilizing Cellular Therapy and Stem Cells are designed to combat neurodegeneration and support recovery in individuals affected by conditions such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and spinal cord injuries. By harnessing the regenerative properties of stem cells, our therapies aim to promote neuronal repair and regeneration. This includes enhancing neuroplasticity—the brain’s ability to reorganize itself—by stimulating the growth of new neural connections and supporting the survival of existing neurons. Our protocols involve administering stem cells that secrete neurotrophic factors, which are essential for neuronal health and function. As a result, patients may experience improvements in cognitive function, motor skills, and overall quality of life.

For more information on how our innovative therapies can help you or your loved ones combat neurodegeneration, contact us today!

Selkoe, D.J., & Hardy, J. (2016). “The Amyloid Hypothesis of Alzheimer’s Disease at 25 Years.” EMBO Molecular Medicine, 8(6), 595-608. DOI: 10.15252/emmm.201606210
Cramer, S.C., et al. (2011). “Harnessing Neuroplasticity for Clinical Applications.” Brain, 134(6), 1591-1609. DOI: 10.1093/brain/awr143
Doidge, N. (2007). The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science. Viking Press.

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