Hydrocortisone
Hydrocortisone
Hydrocortisone is a corticosteroid medication used to treat a wide range of conditions due to its anti-inflammatory and immunosuppressive properties. It is available in various forms, including oral tablets, topical creams and ointments, and injectable formulations.
Uses
- Hormone Replacement: Hydrocortisone is used to replace cortisol in people with adrenal insufficiency (such as Addison’s disease), where the body does not produce enough natural corticosteroids236.
- Anti-inflammatory and Immunosuppressive Therapy: It treats inflammation and suppresses overactive immune responses in conditions like asthma, severe allergies, arthritis, lupus, inflammatory bowel diseases, and certain blood or bone marrow disorders236.
- Dermatological Conditions: Topical hydrocortisone is used to relieve redness, swelling, itching, and discomfort from skin conditions such as eczema, dermatitis, and rashes4789.
How It Works
Hydrocortisone mimics the action of cortisol, a hormone naturally produced by the adrenal glands. It works by binding to glucocorticoid receptors, leading to changes in gene expression that reduce inflammation, decrease immune system activity, and affect the metabolism of carbohydrates, proteins, and fats56. In topical forms, it activates natural substances in the skin to reduce swelling, redness, and itching7.
Side Effects
Common side effects:
Serious side effects (seek medical attention):
- Allergic reactions (rash, swelling, difficulty breathing)
- Sudden weight gain, muscle weakness, unusual bruising
- Swollen face, lower legs, or ankles
- Mood changes, depression, hallucinations
- Eye pain, vision changes
- Signs of infection (fever, sore throat)
- Stomach pain, vomiting, diarrhea136
Topical side effects:
- Burning, itching, irritation, dryness at the application site
- Rarely, thinning skin, stretch marks, or increased risk of skin infections4789
Long-term or high-dose use can lead to osteoporosis, slowed growth in children, adrenal suppression, or Cushing’s syndrome346.
Precautions
- Use with caution in people with infections, diabetes, high blood pressure, osteoporosis, or mental health disorders36.
- Topical forms should not be used on broken or infected skin unless directed by a healthcare provider79.
- Dosage adjustments may be necessary for people with liver or thyroid problems3.
Summary Table
| Formulation | Common Uses | Key Precautions/Notes |
|---|---|---|
| Oral tablets | Adrenal insufficiency, inflammation, allergies | Monitor for systemic side effects, osteoporosis risk |
| Topical creams | Eczema, dermatitis, rashes | Avoid prolonged use on large areas or broken skin |
| Injections | Joint pain, severe inflammation | Risk of infection, adrenal suppression |
Consult with Our Team of Experts Now!
At DrStemCellsThailand (DRSCT)‘s Anti-Aging and Regenerative Medicine Center of Thailand, we emphasize comprehensive evaluations and personalized treatment plans of Cellular Therapy and Stem Cells for managing various health conditions. If you have questions about Hydrocortisone or would like more information on our services, consult with our experts today!
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References:
- Mayo Clinic – Hydrocortisone (oral)1
- Cleveland Clinic – Hydrocortisone Tablets2
- MedlinePlus – Hydrocortisone3
- WebMD – Hydrocortisone topical4
- DrugBank – Hydrocortisone5
- Healthline – Hydrocortisone6
- MedlinePlus – Hydrocortisone Topical7
- Cleveland Clinic – Hydrocortisone Cream8
- Mayo Clinic – Hydrocortisone (topical)9
