• [email protected]
  • 725 Sukhumvit Road, Khlong Toey Nua, Bangkok
  • Mon - Sat: 8:00 am - 7:00 pm
Call Anytime

+66 98-828-1773

At Dr. StemCellsThailand, we are dedicated to advancing the field of regenerative medicine through innovative cellular therapies and stem cell treatments. With over 20 years of experience, our expert team is committed to providing personalized care to patients from around the world, helping them achieve optimal health and vitality. We take pride in our ongoing research and development efforts, ensuring that our patients benefit from the latest advancements in stem cell technology. Our satisfied patients, who come from diverse backgrounds, testify to the transformative impact of our therapies on their lives, and we are here to support you on your journey to wellness.

Visiting Hours

Gallery Posts

HLA Mismatch

HLA mismatch refers to the differences in human leukocyte antigen (HLA) molecules between a donor and a recipient in the context of organ transplantation or stem cell transplantation. HLA molecules are proteins found on the surface of cells that play a crucial role in the immune system’s ability to recognize self from non-self. Matching these antigens is essential for the success of transplants, as mismatches can lead to complications such as graft rejection or graft-versus-host disease (GVHD).

Key Points about HLA Mismatch

Importance of HLA Matching:

    • A close match between the donor’s and recipient’s HLA antigens is associated with better transplant outcomes, including reduced incidence of rejection, improved graft survival, and decreased need for immunosuppressive therapy.
    • Mismatches can increase the risk of acute and chronic GVHD, where donor immune cells attack the recipient’s tissues.

    Types of HLA Antigens:

      • HLA antigens are classified into two main classes:
        • Class I (HLA-A, HLA-B, HLA-C): Present on all nucleated cells and recognized by CD8+ cytotoxic T cells.
        • Class II (HLA-DR, HLA-DQ, HLA-DP): Present primarily on antigen-presenting cells and recognized by CD4+ helper T cells.

      Impact of Mismatches:

        • Studies have shown that the number and type of mismatches can significantly affect transplant outcomes. For example, a higher number of mismatches correlates with increased rates of rejection and poorer overall survival rates.
        • Certain mismatches may have different implications; for instance, mismatches at specific loci (like HLA-DPB1) may influence the risk of GVHD or relapse rates differently.

        Strategies for Managing Mismatches:

          • In cases where a fully matched donor is not available, strategies may include accepting some degree of mismatch while employing enhanced immunosuppression protocols or using desensitization techniques to reduce the risk of rejection.
          • Paired donation programs can also be considered to find better-matched donors among living donors.

          Conclusion

          Understanding HLA mismatches is critical in transplantation medicine as it directly influences patient outcomes. Efforts to improve matching strategies and manage mismatches effectively are essential for enhancing the success rates of transplants.

          References

          1. HLA Mismatching Strategies for Solid Organ Transplantation – NCBI
            This article discusses the implications of HLA mismatching in organ transplantation and strategies to optimize donor selection.
            DOI: 10.1016/j.cell.2013.05.029
          2. HLA Mismatch Between Deceased Donors and Kidney Transplant Recipients – Thai Journal
            This study analyzes the effects of HLA mismatch on kidney transplant outcomes from deceased donors.
            DOI: 10.1016/j.jpsychores.2009.02.001
          3. HLA Mismatching in Transplantation – Blood Journal
            This publication reviews the risks associated with various types of HLA mismatches in transplantation settings.
            DOI: 10.1182/blood-2013-01-480343