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The lower esophageal sphincter (LES) is a critical muscle regulating the passage of food into the stomach and preventing acid reflux. Dysfunction can lead to conditions like GERD (incompetent LES) or achalasia (failure to relax). Below is a synthesis of its pathophysiology, clinical implications, and treatment strategies.

Lower Esophageal Sphincter (LES) Dysfunction

The lower esophageal sphincter (LES) is a critical muscle regulating the passage of food into the stomach and preventing acid reflux. Dysfunction can lead to conditions like GERD (incompetent LES) or

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An esophageal stricture is a narrowing of the esophagus due to scarring, inflammation, or tumors, impairing swallowing. Below is a synthesis of its key aspects, supported by clinical guidelines and research.

Esophageal Stricture (ES)

An esophageal stricture is a narrowing of the esophagus due to scarring, inflammation, or tumors, impairing swallowing. Below is a synthesis of its key aspects, supported by clinical guidelines and research.

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Gastritis is inflammation of the stomach lining, often caused by infections, medications, or lifestyle factors. Below is a synthesis of its key aspects, supported by clinical guidelines and research.

Gastritis (GTT)

Gastritis is inflammation of the stomach lining, often caused by infections, medications, or lifestyle factors. Below is a synthesis of its key aspects, supported by clinical guidelines and research.

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Peptic ulcers (PU) are open sores in the stomach lining (gastric ulcers) or duodenum (duodenal ulcers), caused by impaired mucosal defenses against digestive acids. Below is a synthesis of their key aspects, supported by clinical guidelines and research.

Peptic Ulcers(PU)

Peptic ulcers (PU) are open sores in the stomach lining (gastric ulcers) or duodenum (duodenal ulcers), caused by impaired mucosal defenses against digestive acids. Below is a synthesis of their key

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Esophagogastroduodenoscopy (EGD), also called upper endoscopy, is a minimally invasive procedure to visualize the esophagus, stomach, and duodenum (first part of the small intestine). Below is a detailed overview of its methodology, applications, and recovery.

Esophagogastroduodenoscopy (EGD)

Esophagogastroduodenoscopy (EGD), also called upper endoscopy, is a minimally invasive procedure to visualize the esophagus, stomach, and duodenum (first part of the small intestine). Below is a detailed overview of its

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Pernicious Anemia (PA)

Pernicious anemia (PA) is an autoimmune disorder causing vitamin B12 deficiency due to impaired absorption. It arises from autoantibodies targeting intrinsic factor (IF), a stomach protein essential for B12 uptake, or

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Good syndrome, also termed thymoma-associated immunodeficiency, is a rare disorder characterized by combined B-cell and T-cell immunodeficiency linked to thymoma (thymic epithelial tumor). It manifests with recurrent infections, autoimmune complications, and impaired immune function. Below is a synthesis of its key aspects, supported by current evidence.

Good syndrome

Good syndrome, also termed thymoma-associated immunodeficiency, is a rare disorder characterized by combined B-cell and T-cell immunodeficiency linked to thymoma (thymic epithelial tumor). It manifests with recurrent infections, autoimmune complications, and

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Pure Red Cell Aplasia (PRCA) is a rare hematologic disorder characterized by isolated normocytic anemia due to the bone marrow’s failure to produce red blood cell precursors (erythroblasts). White blood cells and platelets typically remain unaffected. Below is a comprehensive synthesis of its etiology, clinical features, and evidence-based management strategies.

Pure Red Cell Aplasia (PRCA)

Pure Red Cell Aplasia (PRCA) is a rare hematologic disorder characterized by isolated normocytic anemia due to the bone marrow’s failure to produce red blood cell precursors (erythroblasts). White blood cells

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Thymoma (TMA)

Thymoma (TMA): Clinical Overview, Pathology, and Management Thymoma (TMA) is a rare, thymic epithelial neoplasm arising from the thymus, often linked to autoimmune disorders like myasthenia gravis (MG). Below is a

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Paraneoplastic syndromes (PNS) are non-metastatic systemic disorders caused by immune responses or substances produced by cancer cells, often preceding or accompanying malignancy. These syndromes affect multiple organ systems and require prompt diagnosis to guide cancer treatment. Below is a synthesis of their pathophysiology, clinical features, and management strategies.

Paraneoplastic Syndromes (PNS)

Paraneoplastic syndromes (PNS) are non-metastatic systemic disorders caused by immune responses or substances produced by cancer cells, often preceding or accompanying malignancy. These syndromes affect multiple organ systems and require prompt

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