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Category: Digestive Tracts, Gastrointestinal Diseases, Cellular Therapy and Stem Cells

The lower esophageal sphincter (LES) is a critical muscle regulating the passage of food into the stomach and preventing acid reflux. Dysfunction can lead to conditions like GERD (incompetent LES) or achalasia (failure to relax). Below is a synthesis of its pathophysiology, clinical implications, and treatment strategies.

Lower Esophageal Sphincter (LES) Dysfunction

The lower esophageal sphincter (LES) is a critical muscle regulating the passage of food into the stomach and preventing acid reflux. Dysfunction can lead to conditions like GERD (incompetent LES) or

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An esophageal stricture is a narrowing of the esophagus due to scarring, inflammation, or tumors, impairing swallowing. Below is a synthesis of its key aspects, supported by clinical guidelines and research.

Esophageal Stricture (ES)

An esophageal stricture is a narrowing of the esophagus due to scarring, inflammation, or tumors, impairing swallowing. Below is a synthesis of its key aspects, supported by clinical guidelines and research.

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Barrett’s Esophagus (BE) is a premalignant condition where the esophageal lining transforms into intestinal-like tissue due to chronic acid reflux, increasing the risk of esophageal adenocarcinoma. Below is a synthesis of its key aspects, supported by current evidence.

Barrett’s Esophagus(BE)

Barrett’s Esophagus (BE) is a premalignant condition where the esophageal lining transforms into intestinal-like tissue due to chronic acid reflux, increasing the risk of esophageal adenocarcinoma. Below is a synthesis of

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Gastroesophageal reflux disease (GERD) is a chronic condition where stomach acid flows back into the esophagus, causing symptoms like heartburn and tissue damage. Below is a synthesis of its key aspects, supported by clinical guidelines and research.

Gastroesophageal Reflux Disease (GERD)

Gastroesophageal Reflux Disease (GERD): Symptoms, Diagnosis, and Management Gastroesophageal reflux disease (GERD) is a chronic condition where stomach acid flows back into the esophagus, causing symptoms like heartburn and tissue damage.

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Gastritis is inflammation of the stomach lining, often caused by infections, medications, or lifestyle factors. Below is a synthesis of its key aspects, supported by clinical guidelines and research.

Gastritis (GTT)

Gastritis is inflammation of the stomach lining, often caused by infections, medications, or lifestyle factors. Below is a synthesis of its key aspects, supported by clinical guidelines and research.

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Peptic ulcers (PU) are open sores in the stomach lining (gastric ulcers) or duodenum (duodenal ulcers), caused by impaired mucosal defenses against digestive acids. Below is a synthesis of their key aspects, supported by clinical guidelines and research.

Peptic Ulcers(PU)

Peptic ulcers (PU) are open sores in the stomach lining (gastric ulcers) or duodenum (duodenal ulcers), caused by impaired mucosal defenses against digestive acids. Below is a synthesis of their key

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Familial Adenomatous Polyposis (Lynch syndrome), caused by pathogenic variants in DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2, or EPCAM), increases the risk of gastric cancer alongside colorectal and endometrial cancers. Below is a synthesis of gastric cancer risk, surveillance strategies, and evidence-based management in LS.

Familial Adenomatous Polyposis (Lynch syndrome)

Familial Adenomatous Polyposis (Lynch syndrome), caused by pathogenic variants in DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2, or EPCAM), increases the risk of gastric cancer alongside colorectal and endometrial cancers.

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Helicobacter pylori (H. pylori) is a bacterium that infects the stomach lining, causing gastritis, peptic ulcers, and increasing stomach cancer risk. Below is a synthesis of its key aspects, supported by current evidence.

Helicobacter Pylori Infection (HPI)

Helicobacter pylori (H. pylori) is a bacterium that infects the stomach lining, causing gastritis, peptic ulcers, and increasing stomach cancer risk. Below is a synthesis of its key aspects, supported by

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Gastric cancer (GAC), primarily gastric adenocarcinoma, arises from abnormal cell growth in the stomach lining. Early detection is challenging due to nonspecific symptoms, but treatment options vary by stage. Below is a synthesis of its key aspects, supported by current evidence.

Gastric Cancer (GAC)

Gastric cancer (GAC), primarily gastric adenocarcinoma, arises from abnormal cell growth in the stomach lining. Early detection is challenging due to nonspecific symptoms, but treatment options vary by stage. Below is

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Gingivitis (Ggt) is an early stage of gum disease characterized by inflammation, redness, and swelling of the gums (gingiva) due to bacterial plaque buildup. It is reversible with proper oral hygiene but can progress to periodontitis if untreated, leading to tooth loss.

Gingivitis (Ggt)

Gingivitis (Ggt) is an early stage of gum disease characterized by inflammation, redness, and swelling of the gums (gingiva) due to bacterial plaque buildup. It is reversible with proper oral hygiene

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