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Category: Autoimmune and Connective Tissue Diseases, Cellular Therapy and Stem Cells

Rheumatology is a branch of medicine dedicated to the diagnosis and management of disorders primarily involving inflammation in the bones, muscles, joints, and sometimes internal organs3. These conditions, known as rheumatic diseases, often affect the musculoskeletal system and connective tissues25. Rheumatologists are physicians with specialized training in this field3.
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Rheumatology

Rheumatology is a branch of medicine dedicated to the diagnosis and management of disorders primarily involving inflammation in the bones, muscles, joints, and sometimes internal organs3. These conditions, known as rheumatic

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Giant cell arteritis (GCA), also known as temporal arteritis, is an inflammatory autoimmune disease affecting large and medium-sized arteries, most commonly those in the head and temples. It causes inflammation of the arterial walls, leading to narrowing and reduced blood flow, which can result in serious complications such as vision loss.
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Giant Cell Arteritis (Temporal Arteritis)

Giant cell arteritis (GCA), also known as temporal arteritis, is an inflammatory autoimmune disease affecting large and medium-sized arteries, most commonly those in the head and temples. It causes inflammation of

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Inflammatory Myopathy (IFM) is a group of chronic autoimmune disorders characterized by muscle inflammation and weakness. They are often referred to as idiopathic inflammatory myopathies (IIMs) because their exact cause is unknown. The primary types include polymyositis, dermatomyositis, and inclusion body myositis (IBM).
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Inflammatory Myopathy (IFM)

Inflammatory Myopathy (IFM) is a group of chronic autoimmune disorders characterized by muscle inflammation and weakness. They are often referred to as idiopathic inflammatory myopathies (IIMs) because their exact cause is

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Raynaud’s phenomenon (RP) is a disorder characterized by episodic spasms of small blood vessels, primarily affecting the fingers and toes, but it can also involve the nose, lips, ears, and nipples. These spasms cause blood vessels to constrict excessively in response to cold temperatures or emotional stress, leading to reduced blood flow and oxygen supply to the affected areas.
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Raynaud’s Phenomenon (RP)

Raynaud’s phenomenon (RP) is a disorder characterized by episodic spasms of small blood vessels, primarily affecting the fingers and toes, but it can also involve the nose, lips, ears, and nipples.

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Immunohistochemistry (IHC) is a widely used technique for detecting and localizing specific antigens in tissue sections using antigen-antibody interactions. It combines anatomy, physiology, immunology, and biochemistry to provide in situ information about cellular components. Below is a detailed overview of IHC, including its principles, detection methods, and applications.
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Immunohistochemistry (IHC)

Immunohistochemistry (IHC) is a widely used technique for detecting and localizing specific antigens in tissue sections using antigen-antibody interactions. It combines anatomy, physiology, immunology, and biochemistry to provide in situ information

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Flow Cytometry (FC) is a powerful, laser-based technology used to analyze the physical and chemical characteristics of cells or particles in a fluid suspension. It has become an essential tool in research, diagnostics, and clinical practice due to its ability to rapidly provide multi-parametric data on individual cells. Below is a detailed overview of its principles, applications, and recent innovations.
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Flow Cytometry (FC)

Flow Cytometry (FC) is a powerful, laser-based technology used to analyze the physical and chemical characteristics of cells or particles in a fluid suspension. It has become an essential tool in

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Oncolytic virus therapy (OVT) is a promising cancer treatment that leverages viruses to selectively infect and destroy tumor cells while stimulating an antitumor immune response. Below is a detailed overview of its mechanisms, clinical applications, and challenges, supported by current evidence.
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Oncolytic Virus Therapy (OVT)

Oncolytic virus therapy (OVT) is a promising cancer treatment that leverages viruses to selectively infect and destroy tumor cells while stimulating an antitumor immune response. Below is a detailed overview of

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Pernicious Anemia (PA)

Pernicious anemia (PA) is an autoimmune disorder causing vitamin B12 deficiency due to impaired absorption. It arises from autoantibodies targeting intrinsic factor (IF), a stomach protein essential for B12 uptake, or

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Good syndrome, also termed thymoma-associated immunodeficiency, is a rare disorder characterized by combined B-cell and T-cell immunodeficiency linked to thymoma (thymic epithelial tumor). It manifests with recurrent infections, autoimmune complications, and impaired immune function. Below is a synthesis of its key aspects, supported by current evidence.
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Good syndrome

Good syndrome, also termed thymoma-associated immunodeficiency, is a rare disorder characterized by combined B-cell and T-cell immunodeficiency linked to thymoma (thymic epithelial tumor). It manifests with recurrent infections, autoimmune complications, and

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Dendritic cell (DC) vaccination is a promising immunotherapy that leverages the body’s immune system to combat cancer by training dendritic cells—specialized antigen-presenting cells—to recognize and attack tumors. This approach bridges vaccine technology and cellular therapy, offering personalized treatment with reduced systemic toxicity.
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Dendritic Cell Vaccination (DCV)

Dendritic cell (DC) vaccination is a promising immunotherapy that leverages the body’s immune system to combat cancer by training dendritic cells—specialized antigen-presenting cells—to recognize and attack tumors. This approach bridges vaccine

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