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Restless Legs Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological movement disorder characterized by an uncontrollable urge to move the legs, usually accompanied by uncomfortable sensations such as creeping, crawling, tingling, or pulling. These symptoms typically worsen during periods of rest or inactivity, especially in the evening or at night, and can significantly disrupt sleep and quality of life.
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Restless Legs Syndrome (RLS)

Restless Legs Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological movement disorder characterized by an uncontrollable urge to move the legs, usually accompanied by uncomfortable sensations such as creeping,

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Fatigue is a common, multifaceted symptom characterized by an overwhelming sense of tiredness, lack of energy, and reduced capacity for physical and mental work. It can be acute or chronic and may significantly impair daily functioning and quality of life.
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Fatigue

Fatigue is a common, multifaceted symptom characterized by an overwhelming sense of tiredness, lack of energy, and reduced capacity for physical and mental work. It can be acute or chronic and

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Transcranial near-infrared therapy (tNIR), also known as transcranial photobiomodulation (tPBM), is a noninvasive brain stimulation technique that uses low-level near-infrared (NIR) light to penetrate the scalp and skull, modulating brain function at cellular and systemic levels. It has shown promise in treating neurodegenerative diseases, traumatic brain injury, and cognitive disorders by enhancing mitochondrial function, reducing inflammation, and promoting neuroprotection.
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Transcranial Near-Infrared Therapy (tNIR)

Transcranial near-infrared therapy (tNIR), also known as transcranial photobiomodulation (tPBM), is a noninvasive brain stimulation technique that uses low-level near-infrared (NIR) light to penetrate the scalp and skull, modulating brain function

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Lewy body dementia (LBD) is the second most common type of progressive dementia after Alzheimer’s disease. It is caused by abnormal deposits of a protein called alpha-synuclein (Lewy bodies) in brain cells, affecting regions involved in thinking, memory, movement, and autonomic functions16.
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Lewy Body Dementia (LBD)

Lewy body dementia (LBD) is the second most common type of progressive dementia after Alzheimer’s disease. It is caused by abnormal deposits of a protein called alpha-synuclein (Lewy bodies) in brain

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Frontotemporal dementia (FTD) is a group of brain disorders caused by progressive nerve cell loss in the frontal and temporal lobes of the brain, areas associated with personality, behavior, and language. It typically affects people between the ages of 40 and 65 but can occur earlier or later. FTD is characterized by gradual but steady worsening of symptoms that vary depending on the brain regions involved.
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Frontotemporal Dementia (FTD)

Frontotemporal dementia (FTD) is a group of brain disorders caused by progressive nerve cell loss in the frontal and temporal lobes of the brain, areas associated with personality, behavior, and language.

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Lacunar infarcts are small, deep brain infarcts typically measuring 2–20 mm in diameter, resulting from occlusion of a single small perforating artery supplying subcortical regions such as the deep white matter, basal ganglia, thalamus, internal capsule, or pons13. They are a hallmark of cerebral small vessel disease (SVD) and contribute significantly to stroke and vascular cognitive impairment.
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Lacunar Infarcts

Lacunar infarcts are small, deep brain infarcts typically measuring 2–20 mm in diameter, resulting from occlusion of a single small perforating artery supplying subcortical regions such as the deep white matter,

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The retina (RTn) is a thin, light-sensitive layer of tissue lining the back of the eye. It serves as the primary sensory interface for vision, converting incoming light into neural signals that are transmitted to the brain via the optic nerve. The retina’s complex structure and microvascular network make it crucial not only for sight but also as a window into systemic and neurological health.
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Retina (RTn)

The retina (RTn), with its rich microvascular network, shares embryological and physiological similarities with cerebral small vessels, making it a valuable window to study cerebral small vessel disease (CSVD). Recent research

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Small vessel disease (SVD) refers to pathological processes affecting the small arteries, arterioles, capillaries, and venules, leading to impaired blood flow and tissue damage. It is a systemic condition impacting organs with rich microvascular networks, especially the brain, heart, kidneys, and retina.
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Small Vessel Disease (SVD)

Small vessel disease (SVD) refers to pathological processes affecting the small arteries, arterioles, capillaries, and venules, leading to impaired blood flow and tissue damage. It is a systemic condition impacting organs

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Vascular dementia is a type of dementia caused by reduced or impaired blood flow to the brain, leading to brain damage that affects reasoning, planning, judgment, memory, and other cognitive functions. It is the second most common form of dementia after Alzheimer's disease.
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Vascular Dementia (VD)

Vascular dementia is a type of dementia caused by reduced or impaired blood flow to the brain, leading to brain damage that affects reasoning, planning, judgment, memory, and other cognitive functions.

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Bioidentical hormones (BIH) are laboratory-produced hormones derived from plant sources (such as soybeans or yams) that are chemically identical to the hormones naturally produced by the human body, including estrogen, progesterone, and testosterone26. They are primarily used in hormone replacement therapy (HRT) to manage symptoms of menopause, perimenopause, and other hormonal imbalances12.
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Bioidentical Hormones (BIH)

Bioidentical hormones (BIH) are laboratory-produced hormones derived from plant sources (such as soybeans or yams) that are chemically identical to the hormones naturally produced by the human body, including estrogen, progesterone,

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