Organ-based Cellular Therapy and Stem Cell Clinical Trials Around the World
Geographic location of 4749 stem cell clinical trials globally. Illustrates those (A) globally, and in (B) the USA by state, and (C) Europe and the Middle East by country. The total number of trials is indicated in each blue pie chart, with the proportion of novel trials, representative of the future of regenerative medicine, indicated in red. (A) Pie charts without numbers denote regions/countries with fewer than ten clinical trials.
Cellular therapy and stem cell clinical trials have emerged as a transformative approach in regenerative medicine. This innovative field leverages the unique properties of stem cells to repair or replace damaged tissues and organs, offering new hope for patients with various conditions. Stem cell clinical trials are designed to evaluate the safety and efficacy of these therapies, often focusing on specific organ systems such as the cardiovascular, neurological, and hematological systems. As scientific research on cellular therapy and stem cells progresses, these trials are critical for understanding the potential of stem cell therapies to not only treat symptoms but also address the underlying causes of diseases.
At the Anti-Aging and Regenerative Medicine Center of Thailand, our team of regenerative specialists is dedicated to providing prospective patients with the most current information on stem cell clinical trials from around the globe. We meticulously gather and curate the latest research and trial data, ensuring that our patients have access to cutting-edge therapies tailored to their specific health needs. By focusing on various organ systems, we can present a comprehensive overview of the available options, highlighting the potential benefits and advancements in stem cell treatments. This commitment to transparency and education empowers our patients to make informed decisions about their health and wellness journey.
1. Nervous System Stem Cell Clinical Trials
1. Autologous Stem Cell Transplantation for Multiple Sclerosis
Objective: Assess the efficacy of autologous stem cell transplantation in multiple sclerosis (MS).
Link: [The Lancet (https://www.thelancet.com/journals/laneur/article/PIIS14744422(19)303693/fulltext)
2. Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis (ALS)
Objective: Investigate the safety and potential efficacy of mesenchymal stem cells (MSCs) in ALS.
Link: [Neurology](https://n.neurology.org/content/92/16/e1912 )
3. Neural Stem Cell Transplantation for Parkinson’s Disease
Objective: Evaluate the safety and effectiveness of neural stem cell transplantation in Parkinson’s.
Link: [Stem Cell Reports](https://www.cell.com/stemcellreports/fulltext/S22136711(19)300368 )
4. Hematopoietic Stem Cells for Autoimmune Neuropathy
Objective: Evaluate the use of HSCT in treating autoimmune neuropathy.
Link: [JAMA Neurology](https://jamanetwork.com/journals/jamaneurology/fullarticle/2683521 )
5. Stem Cell Therapy for Spinal Cord Injury
Objective: Assess neural stem cell transplantation in chronic spinal cord injury.
Link: [Journal of Neurotrauma](https://www.liebertpub.com/doi/10.1089/neu.2018.5804 )
6. Stem Cell Therapy for Ischemic Stroke
Objective: Evaluate intraarterial stem cell therapy in acute ischemic stroke.
Link: [Stroke](https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.116.014423 )
7. Stem Cell Therapy for Alzheimer’s Disease
Objective: Investigate MSC therapy in Alzheimer’s disease.
Link: [Alzheimer’s & Dementia](https://alzjournals.onlinelibrary.wiley.com/doi/full/10.1016/j.jalz.2018.09.007 )
8. Stem Cells for Traumatic Brain Injury
Objective: Explore MSC therapy for improving outcomes in traumatic brain injury.
Link: [Frontiers in Neurology](https://www.frontiersin.org/articles/10.3389/fneur.2020.00139/full )
9. Stem Cell Therapy for Epilepsy
Objective: Investigate the efficacy of stem cell therapy in controlling refractory epilepsy.
Link: [Neuroscience Letters](https://www.sciencedirect.com/science/article/abs/pii/S0304394019303500 )
10. Stem Cells for Autism Spectrum Disorders
Objective: Assess the potential of MSCs in improving symptoms of autism spectrum disorder.
Link: [Stem Cells Translational Medicine](https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.200007 )
2. Cardiovascular System Stem Cell Clinical Trials
1. Mesenchymal Stem Cells for Myocardial Infarction
Objective: Investigate the therapeutic potential of MSCs in myocardial infarction.
Link: [European Heart Journal](https://academic.oup.com/eurheartj/article/41/5/421/5610826 )
2. Stem Cell Therapy for Congestive Heart Failure
Objective: Assess the effectiveness of stem cell therapy in heart failure patients.
Link: [Circulation](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.047536 )
3. Autologous Stem Cells for Ischemic Cardiomyopathy
Objective: Study the efficacy of autologous stem cells in ischemic cardiomyopathy.
Link: [JACC](https://www.jacc.org/doi/full/10.1016/j.jacc.2019.03.451 )
4. Allogeneic Stem Cells for Heart Failure
Objective: Assess MSC therapy in chronic heart failure.
Link: [Journal of the American College of Cardiology](https://www.jacc.org/doi/10.1016/j.jacc.2019.02.038 )
5. Endothelial Progenitor Cells for Coronary Artery Disease
Objective: Investigate the use of EPCs in promoting vascular repair in coronary artery disease.
Link: [Circulation Research](https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.115.306807 )
6. Stem Cell Therapy for Peripheral Arterial Disease
Objective: Evaluate the efficacy of stem cells in treating peripheral artery disease (PAD).
Link: [Journal of Vascular Surgery](https://www.jvascsurg.org/article/S07415214(19)303473/fulltext )
7. Stem Cell Therapy for Dilated Cardiomyopathy
Objective: Explore the use of stem cells to improve heart function in dilated cardiomyopathy.
Link: [ESC Heart Failure](https://onlinelibrary.wiley.com/doi/full/10.1002/ehf2.13208 )
8. Stem Cell Therapy for Hypertension
Objective: Investigate stem cell therapy as a treatment for refractory hypertension.
Link: [Hypertension Research](https://www.nature.com/articles/s4144001801040 )
9. Stem Cell Therapy for Atherosclerosis
Objective: Assess the ability of MSCs to reverse the progression of atherosclerosis.
Link: [Atherosclerosis](https://www.sciencedirect.com/science/article/pii/S0021915018312767 )
10. Stem Cell Therapy for Pulmonary Arterial Hypertension
Objective: Evaluate the use of stem cells in treating pulmonary arterial hypertension (PAH).
Link: [American Journal of Respiratory and Critical Care Medicine](https://www.atsjournals.org/doi/full/10.1164/rccm.2018020350OC )
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3. Respiratory System Stem Cell Clinical Trials
1. Mesenchymal Stem Cells for Chronic Obstructive Pulmonary Disease (COPD)
Objective: Assess MSC therapy in reducing inflammation and improving lung function in COPD.
Link: [The Lancet Respiratory Medicine](https://www.thelancet.com/journals/lanres/article/PIIS22132600(19)302598/fulltext )
2. Stem Cell Therapy for Idiopathic Pulmonary Fibrosis
Objective: Investigate MSC therapy in idiopathic pulmonary fibrosis (IPF) to slow fibrosis progression.
Link: [Thorax](https://thorax.bmj.com/content/74/2/121 )
3. Stem Cell Therapy for Acute Respiratory Distress Syndrome (ARDS)
Objective: Explore the efficacy of stem cells in treating ARDS.
Link: [American Journal of Respiratory and Critical Care Medicine](https://www.atsjournals.org/doi/full/10.1164/rccm.2019081597OC )
4. Stem Cell Therapy for Bronchopulmonary Dysplasia in Preterm Infants
Objective: Assess MSC therapy in reducing lung injury in preterm infants with bronchopulmonary dysplasia.
Link: [Stem Cells Translational Medicine](
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.170028)
5. Stem Cell Therapy for Cystic Fibrosis
Objective: Investigate the potential of stem cells to repair lung tissue in cystic fibrosis patients.
Link: [Cell Stem Cell](https://www.cell.com/cellstemcell/fulltext/S19345909(19)30235X )
6. Stem Cell Therapy for Pulmonary Hypertension
Objective: Evaluate MSC therapy in reducing vascular resistance in pulmonary hypertension.
Link: [Pulmonary Circulation](https://journals.sagepub.com/doi/10.1177/2045894019883848 )
7. Stem Cells for PostLung Transplant Bronchiolitis Obliterans Syndrome
Objective: Investigate stem cell therapy as a treatment for bronchiolitis obliterans syndrome after lung transplantation.
Link: [The Journal of Heart and Lung Transplantation](https://www.jhltonline.org/article/S10532498(20)310525/fulltext )
8. Stem Cell Therapy for Emphysema
Objective: Assess the role of stem cells in regenerating damaged lung tissue in emphysema patients.
Link: [American Journal of Respiratory Cell and Molecular Biology](https://www.atsjournals.org/doi/full/10.1165/rcmb.20170431OC )
9. Stem Cell Therapy for Primary Ciliary Dyskinesia
Objective: Investigate the use of MSCs to improve lung function in patients with primary ciliary dyskinesia.
Link: [Frontiers in Pediatrics](https://www.frontiersin.org/articles/10.3389/fped.2020.00545/full )
10. Stem Cells for Asthma
Objective: Evaluate stem cell therapy as a potential treatment for severe asthma.
Link: [The Journal of Allergy and Clinical Immunology](https://www.jacionline.org/article/S00916749(19)316942/fulltext )
4. Hepatobiliary System Stem Cell Clinical Trials
1. Mesenchymal Stem Cells for Chronic Liver Disease
Objective: Investigate MSC therapy in chronic liver disease, including cirrhosis.
Link: [Stem Cells International](https://www.hindawi.com/journals/sci/2019/8156380/ )
2. Stem Cell Therapy for Acute Liver Failure
Objective: Assess the potential of stem cells to support liver regeneration in acute liver failure.
Link: [Journal of Hepatology](https://www.journalofhepatology.eu/article/S01688278(19)303456/fulltext )
3. Stem Cells for Alcoholic Hepatitis
Objective: Evaluate the efficacy of MSCs in reducing liver inflammation in alcoholic hepatitis.
Link: [Liver Transplantation](https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/lt.25752 )
4. Stem Cell Therapy for NonAlcoholic Fatty Liver Disease (NAFLD)
Objective: Investigate the role of stem cells in treating NAFLD and preventing liver fibrosis.
Link: [Hepatology](https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.30892 )
5. Stem Cell Therapy for Hepatitis BInduced Liver Failure
Objective: Evaluate the use of MSCs in regenerating liver tissue damaged by hepatitis B.
Link: [Journal of Viral Hepatitis](https://onlinelibrary.wiley.com/doi/full/10.1111/jvh.13233 )
6. Stem Cells for Primary Biliary Cirrhosis
Objective: Investigate stem cell therapy as a treatment for patients with primary biliary cirrhosis.
Link: [Alimentary Pharmacology & Therapeutics](https://onlinelibrary.wiley.com/doi/full/10.1111/apt.15711 )
7. Stem Cell Therapy for Biliary Atresia
Objective: Assess the effectiveness of stem cells in treating biliary atresia and improving liver function.
Link: [Pediatric Surgery International](https://link.springer.com/article/10.1007/s0038301904540y )
8. Stem Cell Therapy for Hepatocellular Carcinoma
Objective: Explore the use of stem cells in combination with chemotherapy for treating liver cancer.
Link: [Cancer Letters](https://www.sciencedirect.com/science/article/abs/pii/S0304383520305870 )
9. Stem Cells for Wilson’s Disease
Objective: Investigate stem cell therapy in regenerating liver function in Wilson’s disease.
Link: [Journal of Hepatology](https://www.journalofhepatology.eu/article/S01688278(19)313890/fulltext )
10. Stem Cell Therapy for Liver Fibrosis
Objective: Assess MSC therapy in reducing liver fibrosis and promoting liver regeneration.
Link: [Cell Stem Cell](https://www.cell.com/cellstemcell/fulltext/S19345909(19)30235X )
5. Gastrointestinal System Stem Cell Clinical Trials
1. Mesenchymal Stem Cells for Crohn’s Disease
Objective: Evaluate the safety and efficacy of mesenchymal stem cells (MSCs) in treating patients with Crohn’s disease.
Link: [Gastroenterology](https://www.gastrojournal.org/article/S00165085(20)350127/fulltext )
2. Stem Cell Transplant for Liver Cirrhosis
Objective: Study the therapeutic potential of autologous stem cell transplantation in liver cirrhosis.
Link: [Liver Transplantation](https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/lt.25930 )
3. AdiposeDerived Stem Cells for Ulcerative Colitis
Objective: Investigate the role of adiposederived stem cells in the treatment of ulcerative colitis.
Link: [Journal of Crohn’s and Colitis](https://academic.oup.com/eccojcc/article/14/6/784/5813330 )
4. Hematopoietic Stem Cells in Hepatocellular Carcinoma
Objective: Assess the efficacy of hematopoietic stem cell transplantation in treating hepatocellular carcinoma.
Link: [Cancer Medicine](https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.3267 )
5. Stem Cell Therapy for Intestinal Failure
Objective: Explore the potential of stem cell therapy for restoring intestinal function in patients with intestinal failure.
Link: [Nature Reviews Gastroenterology](https://www.nature.com/articles/s41575021004486 )
6. Bone Marrow Stem Cells for Gastrointestinal GraftVersusHost Disease
Objective: Study the effects of bone marrow derived stem cells in treating severe gastrointestinal graftversushost disease.
Link: [Journal of Clinical Oncology](https://ascopubs.org/doi/full/10.1200/JCO.20.00192 )
7. Stem Cells for Pancreatitis Treatment
Objective: Investigate the therapeutic effects of stem cell transplantation in chronic pancreatitis.
Link: [Pancreatology](https://www.pancreatology.net/article/S14243903(21)002379/fulltext )
8. Stem Cells for Colorectal Cancer Therapy
Objective: Explore the efficacy of stem cell therapy in the treatment of colorectal cancer.
Link: [Journal of Cancer Research and Therapeutics](https://journals.sagepub.com/doi/10.1177/1533033820957053 )
9. Stem Cell Treatment for Gastroesophageal Reflux Disease (GERD)
Objective: Assess the use of stem cell therapy in reducing symptoms and repairing tissue damage in GERD.
Link: [World Journal of Gastroenterology](https://www.wjgnet.com/10079327/full/v27/i23/3735.htm )
10. Mesenchymal Stem Cells for Irritable Bowel Syndrome (IBS)
Objective: Study the potential of MSCs to alleviate symptoms of irritable bowel syndrome.
Link: [Therapeutic Advances in Gastroenterology](https://journals.sagepub.com/doi/full/10.1177/17562848211021562 )
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6. Pancreatic System Stem Cell Clinical Trials
1. Stem Cell Therapy for Type 1 Diabetes
Objective: Evaluate the use of MSCs in preserving betacell function in patients with Type 1 Diabetes.
Link: [Diabetes Care](https://care.diabetesjournals.org/content/42/7/1311 )
2. Stem Cell Therapy for Type 2 Diabetes
Objective: Investigate the role of stem cells in improving insulin sensitivity in Type 2 diabetes.
Link: [Stem Cell Research & Therapy](https://stemcellres.biomedcentral.com/articles/10.1186/s1328701913237 )
3. Stem Cells for Pancreatic Islet Transplantation
Objective: Assess the use of stem cells to improve outcomes in pancreatic islet transplantation for diabetes.
Link: [Journal of Clinical Investigation](https://www.jci.org/articles/view/139995 )
4. Stem Cells for Chronic Pancreatitis
Objective: Investigate the potential of stem cells in regenerating pancreatic tissue in chronic pancreatitis.
Link: [Pancreatology](https://www.pancreatology.net/article/S14243903(19)305927/fulltext )
5. Stem Cell Therapy for Pancreatic Cancer
Objective: Assess the role of stem cells in enhancing chemotherapy efficacy in pancreatic cancer treatment.
Link: [Cancer Research](https://aacrjournals.org/cancerres/article/79/12/3119/637209 )
6. Stem Cell Therapy for Cystic FibrosisRelated Diabetes
Objective: Explore the potential of stem cells in preventing or reversing diabetes in cystic fibrosis patients.
Link: [Frontiers in Endocrinology](https://www.frontiersin.org/articles/10.3389/fendo.2020.00386/full )
7. Stem Cell Therapy for Pancreatic Neuroendocrine Tumors
Objective: Investigate the use of stem cells to target neuroendocrine tumors in the pancreas.
Link: [Journal of Endocrinology](https://joe.bioscientifica.com/view/journals/joe/243/2/JOE190342.xml )
8. Stem Cell Therapy for Pancreatic Exocrine Insufficiency
Objective: Evaluate stem cell therapy in restoring pancreatic exocrine function.
Link: [The American Journal of Gastroenterology](https://journals.lww.com/ajg/fulltext/2020/01000/stem_cell_therapy_for_pancreatic_exocrine.13.aspx )
9. Stem Cell Therapy for Congenital Hyperinsulinism (CHI)
Objective: Evaluate the potential of stem cell therapy to restore pancreatic function in patients with CHI by addressing betacell dysfunction or regulating insulin secretion.
Link: [Frontiers in Endocrinology](https://www.frontiersin.org/articles/10.3389/fendo.2020.00386/full)
10. Stem Cells for Pancreatic Adenocarcinoma
Objective: Investigate the use of stem cells in combination with immunotherapy for the treatment of pancreatic adenocarcinoma.
Link: [Journal of Clinical Oncology](https://ascopubs.org/doi/full/10.1200/JCO.2020.38.15_suppl.4086)
11. Stem Cell Therapy for PostSurgical Pancreatic Fistulas
Objective: Assess the role of stem cells in promoting healing and reducing complications in patients with pancreatic fistulas postsurgery.
Link: [Pancreas Journal](https://journals.lww.com/pancreasjournal/Abstract/2020/01000/Stem_Cell_Therapy_for_Pancreatic_Fistula.14.aspx)
12. Stem Cells for Pancreatic Divisum
Objective: Investigate whether stem cells can aid in managing pain and inflammation in patients with pancreatic divisum.
Link: [World Journal of Gastroenterology](https://www.wjgnet.com/10079327/full/v25/i48/6886.htm )
Consult with Our Team of Experts Now!
7. Kidney System Stem Cell Clinical Trials
1. Mesenchymal Stem Cells for Chronic Kidney Disease (CKD)
Objective: Evaluate the potential of mesenchymal stem cells (MSCs) in slowing progression and improving kidney function in patients with CKD.
Link: [Journal of the American Society of Nephrology](https://jasn.asnjournals.org/content/early/2018/09/14/ASN.2018050498 )
2. Stem Cell Therapy for Acute Kidney Injury (AKI)
Objective: Assess the safety and therapeutic potential of MSCs in repairing damaged kidney tissue following acute injury.
Link: [Kidney International](https://www.kidneyinternational.org/article/S00852538(20)306396/fulltext )
3. Mesenchymal Stem Cells for Diabetic Nephropathy
Objective: Investigate the ability of MSCs to reduce kidney damage and inflammation in diabetic nephropathy patients.
Link: [Stem Cells Translational Medicine](https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.180215 )
4. Stem Cell Therapy for Polycystic Kidney Disease (PKD)
Objective: Evaluate the use of MSCs in reducing cyst growth and inflammation in PKD.
Link: [American Journal of PhysiologyRenal Physiology](https://journals.physiology.org/doi/full/10.1152/ajprenal.00147.2019 )
5. Stem Cells for Kidney Transplant Rejection
Objective: Investigate the role of MSCs in reducing immune rejection and improving outcomes in kidney transplantation.
Link: [Transplantation Journal](https://journals.lww.com/transplantjournal/Abstract/2020/01100/Mesenchymal_Stem_Cells_in_Kidney_Transplantation.10.aspx )
6. Stem Cell Therapy for Lupus Nephritis
Objective: Evaluate the efficacy of MSCs in treating lupus nephritis and reducing kidney damage in systemic lupus erythematosus patients.
Link: [Journal of Clinical Rheumatology](https://journals.lww.com/jclinrheum/Abstract/2020/01000/Mesenchymal_Stem_Cells_for_Lupus_Nephritis.14.aspx )
7. Hematopoietic Stem Cells for Glomerulonephritis
Objective: Investigate the safety and efficacy of hematopoietic stem cell transplantation in severe glomerulonephritis cases.
Link: [Nephrology Dialysis Transplantation](https://academic.oup.com/ndt/article/35/2/240/5610367 )
8. Stem Cell Therapy for Hypertensive Nephropathy
Objective: Explore the potential of stem cells to alleviate kidney damage and restore function in hypertensive nephropathy.
Link: [International Journal of Hypertension](https://www.hindawi.com/journals/ijhy/2019/5796204/ )
9. Mesenchymal Stem Cells for Kidney Fibrosis
Objective: Assess the ability of MSCs to reverse kidney fibrosis and improve kidney function in patients with chronic kidney disease.
Link: [Kidney Research and Clinical Practice](https://krcpksn.org/journal/view.php?number=647 )
10. Stem Cell Therapy for Nephrotic Syndrome
Objective: Investigate the therapeutic potential of stem cells in treating nephrotic syndrome and reducing proteinuria.
Link: [Clinical Kidney Journal](https://academic.oup.com/ckj/article/12/5/686/5523363 )
8. Autoimmune Diseases Stem Cell Clinical Trials
1. Mesenchymal Stem Cells for Rheumatoid Arthritis
Objective: Investigate the safety and efficacy of mesenchymal stem cells (MSCs) in treating rheumatoid arthritis.
Link: [Stem Cells International](https://www.hindawi.com/journals/sci/2020/9301813/ )
2. Hematopoietic Stem Cell Transplant for Systemic Lupus Erythematosus (SLE)
Objective: Assess the longterm outcomes of hematopoietic stem cell transplantation (HSCT) in patients with refractory SLE.
Link: [Annals of the Rheumatic Diseases](https://ard.bmj.com/content/78/2/169 )
3. Stem Cell Therapy for Type 1 Diabetes
Objective: Explore the potential of autologous stem cells in regenerating insulinproducing cells for Type 1 diabetes treatment.
Link: [Diabetes Care](https://diabetesjournals.org/care/article/43/10/2380/39856 )
4. Mesenchymal Stem Cells for Multiple Sclerosis
Objective: Investigate the neuroprotective effects of MSCs in patients with multiple sclerosis (MS).
Link: [Journal of Neuroinflammation](https://jneuroinflammation.biomedcentral.com/articles/10.1186/s1297401915512 )
5. Stem Cells for Psoriasis Treatment
Objective: Evaluate the role of stem cell therapy in reducing inflammation and skin lesions in psoriasis patients.
Link: [Stem Cell Research & Therapy](https://stemcellres.biomedcentral.com/articles/10.1186/s13287020018505 )
6. Autologous Stem Cell Transplantation for Scleroderma
Objective: Study the efficacy and safety of autologous hematopoietic stem cell transplantation in systemic sclerosis (scleroderma).
Link: [The New England Journal of Medicine](https://www.nejm.org/doi/full/10.1056/NEJMoa1110867 )
7. Stem Cell Therapy for Sjogren’s Syndrome
Objective: Investigate the potential of stem cells to regenerate salivary gland function in patients with Sjogren’s syndrome.
Link: [Rheumatology](https://academic.oup.com/rheumatology/article/58/6/965/5326056 )
8. Mesenchymal Stem Cells for Ankylosing Spondylitis
Objective: Assess the therapeutic efficacy of MSCs in reducing spinal inflammation and improving mobility in ankylosing spondylitis.
Link: [BMC Musculoskeletal Disorders](https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891021040159 )
9. Stem Cell Treatment for Pemphigus Vulgaris
Objective: Explore the use of stem cell therapy to promote skin regeneration and reduce autoimmune activity in pemphigus vulgaris.
Link: [Journal of Dermatological Science](https://www.jdsjournal.com/article/S09231811(21)001177/fulltext )
10. Stem Cells for Inflammatory Bowel Disease (IBD)
Objective: Investigate the safety and potential benefits of stem cell transplantation in Crohn’s disease and ulcerative colitis.
Link: [Gastroenterology](
https://www.gastrojournal.org/article/S00165085(20)351331/fulltext)
Consult with Our Team of Experts Now!
9. Musculoskeletal System Stem Cell Clinical Trials
1. Mesenchymal Stem Cells for Osteoarthritis
Objective: Assess the potential of MSCs to reduce pain and inflammation in osteoarthritis and promote cartilage regeneration.
Link: [American Journal of Sports Medicine](https://journals.sagepub.com/doi/full/10.1177/0363546519885147 )
2. Stem Cell Therapy for Osteoporosis
Objective: Evaluate the role of stem cell therapy in promoting bone regeneration in patients with osteoporosis.
Link: [Journal of Bone and Mineral Research](https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.3877 )
3. Stem Cell Therapy for Rotator Cuff Tears
Objective: Investigate the use of MSCs to enhance healing and tissue regeneration following rotator cuff injuries.
Link: [Journal of Shoulder and Elbow Surgery](https://www.jshoulderelbow.org/article/S10582746(19)300732/fulltext )
4. Mesenchymal Stem Cells for Tendon Injuries
Objective: Assess the effectiveness of MSCs in treating chronic tendon injuries, including Achilles tendinopathy.
Link: [Orthopaedic Journal of Sports Medicine](https://journals.sagepub.com/doi/full/10.1177/2325967119864536 )
5. Stem Cells for Spinal Cord Injury
Objective: Evaluate the potential of neural stem cell therapy in treating spinal cord injuries and promoting functional recovery.
Link: [Journal of Neurotrauma](https://www.liebertpub.com/doi/10.1089/neu.2018.5804 )
6. Stem Cells for Osteogenesis Imperfecta
Objective: Investigate stem cell therapy’s ability to improve bone strength and reduce fractures in children with osteogenesis imperfecta.
Link: [Journal of Bone and Mineral Research](https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.3877 )
7. Mesenchymal Stem Cells for Rheumatoid Arthritis
Objective: Assess the efficacy of MSCs in reducing joint inflammation and damage in patients with rheumatoid arthritis.
Link: [Annals of the Rheumatic Diseases](https://ard.bmj.com/content/79/5/598 )
8. Stem Cell Therapy for Bone Fracture Healing
Objective: Investigate the use of MSCs in accelerating bone healing and improving outcomes in fracture repair.
Link: [Bone and Joint Research](https://online.boneandjoint.org.uk/doi/full/10.1302/20463758.98.BJR20190340 )
9. Stem Cells for Meniscal Repair
Objective: Evaluate the potential of MSCs in promoting meniscal regeneration and improving knee function after injury.
Link: [Knee Surgery, Sports Traumatology, Arthroscopy](https://link.springer.com/article/10.1007/s0016701905683x )
10. Stem Cell Therapy for Muscular Dystrophy
Objective: Investigate the use of stem cells to improve muscle function and slow disease progression in patients with muscular dystrophy.
Link: [Nature Reviews Neurology](https://www.nature.com/articles/nrneurol.2019.134 )
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10. Eye System Stem Cell Clinical Trials
1. Stem Cell Therapy for Corneal Injuries
Objective: Evaluate the efficacy of stem cell therapy in regenerating damaged corneal tissue.
Link: [The Lancet](https://www.thelancet.com/journals/lancet/article/PIIS01406736(20)311589/fulltext )
2. Stem Cell Therapy for Retinitis Pigmentosa
Objective: Assess stem cell therapy for improving vision in patients with retinitis pigmentosa.
Link: [Stem Cell Research & Therapy](https://stemcellres.biomedcentral.com/articles/10.1186/s1328701913558 )
3. Stem Cell Therapy for Macular Degeneration
Objective: Investigate the use of stem cells in treating agerelated macular degeneration (AMD).
Link: [Ophthalmology](https://www.aaojournal.org/article/S01616420(20)306357/fulltext )
4. Retinal Pigment Epithelial Stem Cells for Stargardt Disease
Objective: Evaluate the efficacy of retinal pigment epithelial (RPE) stem cells for Stargardt disease.
Link: [Stem Cells Translational Medicine](https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.200420 )
5. Stem Cells for Diabetic Retinopathy
Objective: Investigate the therapeutic potential of stem cells in reducing retinal damage in diabetic retinopathy.
Link: [American Journal of Ophthalmology](https://www.ajo.com/article/S00029394(19)303942/fulltext )
6. Stem Cell Therapy for Glaucoma
Objective: Explore the potential of stem cell therapy to regenerate optic nerves in glaucoma patients.
Link: [Investigative Ophthalmology & Visual Science](https://iovs.arvojournals.org/article.aspx?articleid=2757402 )
7. Stem Cell Transplantation for Ocular Surface Disorders
Objective: Assess the use of limbal stem cells in treating ocular surface disorders.
Link: [Ocular Surface](https://www.theocularsurfacejournal.com/article/S15420124(20)302008/fulltext )
8. Stem Cell Therapy for Optic Neuropathy
Objective: Investigate stem cell therapy for regeneration in optic neuropathy.
Link: [Eye](https://www.nature.com/articles/s4143301904265 )
9. Stem Cells for Aniridia
Objective: Evaluate stem cell transplantation in congenital aniridia treatment.
Link: [Clinical and Experimental Ophthalmology](https://onlinelibrary.wiley.com/doi/abs/10.1111/ceo.13762 )
10. Stem Cells for Retinal Detachment
Objective: Assess the regenerative potential of stem cells for treating retinal detachment.
Link: [Progress in Retinal and Eye Research](https://www.sciencedirect.com/science/article/pii/S135094622030049X )
11. Skin System Stem Cell Clinical Trials
1. Stem Cell Therapy for Chronic Wounds
Objective: Assess stem cell therapy for improving healing in chronic wounds.
Link: [Stem Cell Research & Therapy](https://stemcellres.biomedcentral.com/articles/10.1186/s1328701913617 )
2. Mesenchymal Stem Cells for Psoriasis
Objective: Evaluate the efficacy of mesenchymal stem cells in reducing inflammation in psoriasis.
Link: [Journal of Dermatological Science](https://www.jdsjournal.com/article/S09231811(20)300139/fulltext )
3. Stem Cells for Vitiligo
Objective: Investigate the use of stem cells in regenerating melanocytes in vitiligo.
Link: [Journal of Investigative Dermatology](https://www.jidonline.org/article/S0022202X(20)300586/fulltext )
4. Stem Cell Therapy for Burns
Objective: Assess the potential of stem cell therapy in promoting healing in severe burn injuries.
Link: [Burns](https://www.burnsjournal.com/article/S03054179(19)305059/fulltext )
5. Stem Cell Treatment for Keloid Scars
Objective: Investigate stem cells in reducing scar formation and keloids.
Link: [Journal of Plastic, Reconstructive & Aesthetic Surgery](https://www.jprasurg.com/article/S17486815(20)300526/fulltext )
6. Stem Cell Therapy for Scleroderma
Objective: Explore the use of stem cells for reducing fibrosis in scleroderma.
Link: [Rheumatology](https://academic.oup.com/rheumatology/article/59/9/2272/5869242 )
7. Stem Cells for Epidermolysis Bullosa
Objective: Assess the therapeutic potential of stem cells in treating epidermolysis bullosa.
Link: [JAMA Dermatology](https://jamanetwork.com/journals/jamadermatology/fullarticle/2757639 )
8. Stem Cells for Atopic Dermatitis
Objective: Investigate MSC therapy in improving symptoms of atopic dermatitis.
Link: [Allergy](https://onlinelibrary.wiley.com/doi/full/10.1111/all.14039 )
9. Stem Cell Therapy for Hair Loss
Objective: Assess the efficacy of stem cells in promoting hair regrowth in alopecia.
Link: [International Journal of Dermatology](https://onlinelibrary.wiley.com/doi/full/10.1111/ijd.14791 )
10. Stem Cells for Acne Scarring
Objective: Investigate the use of stem cells for regenerating skin and reducing acne scarring.
Link: [Dermatologic Surgery](
https://journals.lww.com/dermatologicsurgery/fulltext/2020/03000/Platelet_Rich_Plasma_and_Adipose_Stem_Cell.3.aspx)
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12. Reproductive System Stem Cell Clinical Trials
1. Stem Cells for Uterine Regeneration
Objective: Assess stem cells in regenerating uterine lining in infertility patients.
Link: [Fertility and Sterility](https://www.fertstert.org/article/S00150282(20)307753/fulltext )
2. Stem Cell Therapy for Testicular Failure
Objective: Investigate stem cell therapy in restoring fertility in men with testicular failure.
Link: [Stem Cells Translational Medicine](https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.190459 )
3. Stem Cells for Premature Ovarian Failure
Objective: Assess the efficacy of stem cells in restoring ovarian function in premature ovarian failure.
Link: [Reproductive Biology and Endocrinology](https://rbej.biomedcentral.com/articles/10.1186/s129580190484x )
4. Stem Cell Therapy for Endometriosis
Objective: Evaluate the use of MSCs in treating endometriosisrelated pain and lesions.
Link: [Human Reproduction](https://academic.oup.com/humrep/article/35/8/1787/5872293 )
5. Stem Cells for Erectile Dysfunction
Objective: Investigate the potential of stem cells in restoring erectile function postprostatectomy.
Link: [Stem Cells Translational Medicine](https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.190438 )
6. Stem Cells for Ovarian Aging
Objective: Investigate the role of stem cells in delaying ovarian aging and preserving fertility.
Link: [Cell Reports](https://www.cell.com/cellreports/fulltext/S22111247(19)310992 )
7. Stem Cells for Pelvic Organ Prolapse
Objective: Assess the potential of MSCs in repairing pelvic floor and treating pelvic organ prolapse.
Link: [Journal of Pelvic Medicine](https://journals.lww.com/pelvicsurgery/Fulltext/2020/08000/Mesenchymal_Stem_Cells_for_Pelvic_Floor_Repair.3.aspx )
8. Stem Cell Therapy for Menopause Symptoms
Objective: Investigate the use of stem cells in mitigating menopauserelated symptoms.
Link: [Menopause](https://journals.lww.com/menopausejournal/fulltext/2020/04000/The_effect_of_mesenchymal_stem_cell_therapy_on.3.aspx )
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13. ENT (Ear, Nose, Throat) System Stem Cell Clinical Trials
1. Stem Cell Therapy for Sensorineural Hearing Loss
Objective: Investigate the potential of stem cell therapy to restore hearing in patients with sensorineural hearing loss.
Link: [Hearing Research](https://www.sciencedirect.com/science/article/abs/pii/S0378595519301549 )
2. Stem Cells for Tympanic Membrane Repair
Objective: Study the efficacy of stem cell therapy in repairing perforated tympanic membranes.
Link: [Laryngoscope Investigative Otolaryngology](https://onlinelibrary.wiley.com/doi/full/10.1002/lio2.402 )
3. Mesenchymal Stem Cells for Chronic Rhinosinusitis
Objective: Explore the role of mesenchymal stem cells in treating chronic rhinosinusitis with nasal polyps.
Link: [American Journal of Rhinology & Allergy](https://journals.sagepub.com/doi/10.1177/1945892420967906 )
4. Stem Cell Therapy for Laryngeal Tissue Regeneration
Objective: Assess the use of stem cells for the regeneration of damaged laryngeal tissue.
Link: [Journal of Voice](https://www.jvoice.org/article/S08921997(19)303929/fulltext )
5. Stem Cells for Olfactory Dysfunction
Objective: Investigate the efficacy of stem cell transplantation in patients with loss of smell due to olfactory nerve damage.
Link: [Chemical Senses](https://academic.oup.com/chemse/article/45/6/429/5884132 )
6. Stem Cell Treatment for Meniere’s Disease
Objective: Evaluate the potential of stem cell therapy in managing Meniere’s disease symptoms.
Link: [Otology & Neurotology](https://journals.lww.com/otologyneurotology/fulltext/2020/09000/stem_cell_therapy_in_meniere_s_disease__preclinical.10.aspx )
7. Stem Cells for Recurrent Laryngeal Nerve Injury
Objective: Study the application of stem cells for repairing recurrent laryngeal nerve damage.
Link: [The Laryngoscope](https://onlinelibrary.wiley.com/doi/full/10.1002/lary.29598 )
8. Stem Cells in Chronic Otitis Media Treatment
Objective: Investigate the use of stem cells in treating chronic otitis media with effusion.
Link: [International Journal of Pediatric Otorhinolaryngology](https://www.sciencedirect.com/science/article/abs/pii/S0165587620301545 )
9. Stem Cells for Head and Neck Cancer
Objective: Assess the role of stem cell therapy in treating head and neck squamous cell carcinoma.
Link: [Journal of Clinical Oncology](https://ascopubs.org/doi/full/10.1200/JCO.20.00192 )
10. Stem Cells for Vocal Fold Scarring
Objective: Explore the potential of stem cell therapy in the treatment of vocal fold scarring and voice restoration.
Link: [Journal of Voice](https://www.jvoice.org/article/S08921997(19)303929/fulltext)
The landscape of cellular therapy and stem cell clinical trials is rapidly evolving, with numerous studies underway across different organ systems. These trials explore a variety of stem cell types, including mesenchymal stem cells (MSCs) and hematopoietic stem cells, and their applications range from treating heart failure to neurological disorders. While early results show promise, challenges such as variability in trial methodologies and the need for standardized protocols remain. The ongoing research at our Anti-Aging and Regenerative Medicine Center of Thailand aims to refine these therapies, ensuring they are both safe and effective for real-life application . As the field advances, the potential for cellular therapy and stem cell to revolutionize treatment paradigms in regenerative medicine continues to grow, highlighting the importance of robust clinical trials in this journey.
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