Intranasal inhalation

Intranasal Inhalation of Cellular Therapy and Stem Cells

Intranasal inhalation of Cellular Therapy and Stem Cells is an innovative approach that allows for non-invasive delivery of therapeutic agents directly to the brain, bypassing the blood-brain barrier (BBB). This method has gained attention for its potential in treating various neurological conditions, including Parkinson’s disease.

Advantages of Intranasal Delivery

• Non-Invasive: The intranasal route is less invasive compared to traditional methods such as intrathecal or intravenous injections, making it a more patient-friendly option.
• Direct Access to the CNS: By utilizing the olfactory pathways, stem cells can quickly reach the central nervous system (CNS), enhancing therapeutic efficacy.
• Repeatability: This method allows for repeated administrations without significant discomfort, which is beneficial for chronic conditions requiring ongoing treatment.

Mechanisms of Action

The delivery of Cellular Therapy and Stem Cells via the intranasal route facilitates their migration from the nasal cavity into the brain. Studies have shown that stem cells can cross the olfactory epithelium and enter the brain through the cribriform plate, allowing them to reach targeted areas affected by disease.

Clinical Research

1. Optimization of Intranasal Delivery
   Research has focused on improving the effectiveness of intranasal delivery by optimizing conditions such as cell concentration and administration techniques. This study demonstrated that human neural stem cells (hNSCs) could effectively migrate to brain regions after intranasal administration, showing promise for treating hypoxic-ischemic encephalopathy.
   Dove Press – Optimization of an Intranasal Route DOI: 10.2147/NDT.S189488.
2. Intranasal Delivery for Glioma Treatment
   This review discusses how intranasal delivery can improve the efficacy of stem-cell-based therapies against glioma by facilitating direct migration from the nasal cavity to tumor sites, highlighting its potential advantages over systemic administration.
   PMC5847369 DOI: 10.3390/cancers11091289.
3. Nasal Administration of Stem Cells
   This study investigates the use of mesenchymal stem cells (MSCs) delivered via the nasal route to regenerate brain tissue following ischemic events, demonstrating significant improvements in sensorimotor function and reduction in brain lesion size.
   Nature – Nasal Administration of Stem Cells DOI: 10.1203/PDR.0b013e3181f2b9c6.
4. Advances in Intranasal Application of Stem Cells
   This review highlights advances in intranasal application techniques, discussing various cell types and neurological disorders that can benefit from this delivery method while addressing challenges and future directions in research.
   PMC7992869 DOI: 10.3390/ijms21176435.
5. State of the Art Review of Cell Therapy in Lung Disease
   Although focused on lung diseases, this article discusses inhalation therapy’s advancements and potential applications for aerosolized stem cell delivery, which could inform similar approaches for CNS therapies.
   MDPI – State of the Art Review DOI: 10.3390/ijms21176435.